AB0231 PROGNOSTIC UTILITY OF METACARPAL BONE MINERAL DENSITY MEASUREMENT IN PATIENTS WITH RECENT-ONSET ARTHRITIS BY ASSESSMENT OF RADIOGRAPHIC PROGRESSION AT 2-YEAR FOLLOW-UP

Background Rheumatoid arthritis (RA) and osteoporosis (OP) have a complex interplay in terms of pathogenic mechanisms. In this regard, radiogrammetry (DXR) the hand, technique that measures bone mineral density (BMD) at central metacarpals (MC), is associated with worse prognosis patients RA (1). However, DXR an expensive technique, not very accessible our environment. Our group demonstrated excellent reproducibility MC measurement by DXA (2) good correlation between BMD measurements obtained (3). Objectives To evaluate if baseline non dominant measured can be used as prognostic marker, resembling DXR, early (EA). Methods A total 378 subjects from PEARL (Princesa Early Arthritis Register Longitudinal) study underwent 2 nd to 4 th MC’s diaphyseal area hand (Hologic 4500). sociodemographic, clinical laboratory parameters, therapeutic data radiographic findings are collected protocol. Radiographic progression was evaluated hands blind expert rheumatologist assessing erosion scale modified SvdH index both two year follow-up visit. predictive value DXA, multivariate models were fitted using generalized linear Stata 14.0 for Windows (Stata Corp LP, College Station, TX, USA). The dependent variables remission (SDAI<3.3) after years follow-up. Both adjusted classic affect such age, sex body mass (BMI), cumulative DMARD treatment disease activity model. Results After adjustment BMI: a) those tended show higher (p=0.328); b) had significantly lower shown Figure 1(p=0.001). Conclusion registry EA, we detected basal diaphysis bones, assessed greater adjusting main factors influencing BMD. Therefore, could conclude low initial constitute poor factor EA. 1. Correlation mean 2-4th bones radiographyc assesed radiological years, BMI, calculated margins command base don analysis. References [1]Haugeberg G, Lodder MC, Lems WF, Uhlig T, Ørstavik RE, Dijkmans B a. C, et al. Ann Rheum Dis october 2004;63(10):1331-4. [2]Llorente I, Merino L, Escolano E, Quintanilla DM, García-Vadillo JA, González- Álvaro C Clin J Densitom 2020;23(4):678-84 [3]Ann Dis, volumen 78, supplement 2, 2019, page A942 Disclosure Interests Irene Llorente Speakers bureau: UCB, Jannsen, Lilly, Gedeon Richter, Ana Ortiz: None declared, ANA MARIA FERNANDEZ ORTIZ: Alberto García-Vadillo: José Ivorra: Luis Rodriguez Rodriguez: Rosario Garcia-Vicuna: Santos Castañeda: Isidoro González-Álvaro: declared